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Sucralfate exhibits a local effect in the gastrointestinal tract as it is minimally absorbed systemically. Once administered, it binds to ulcerated areas, forming a viscous, protective barrier. This protective layer shields the ulcer site from pepsin, gastric acid, and bile, facilitating healing. The small amount absorbed is primarily excreted through the urine.
- Children (<14 years): Not recommended due to lack of safety data.
- Elderly: No specific dosage adjustment required.
- Renal Dysfunction: Use with caution; monitor for aluminum toxicity.
- Driving/Operating Machinery: Avoid if dizziness or drowsiness occurs.
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✅ Description:
Ulfix 1000 is prescribed for individuals aged 14 years and older in the management of:
- Duodenal ulcers
- Gastric ulcers
- Chronic gastritis
- Prevention of gastrointestinal bleeding associated with stress ulcers in critically ill patients
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Therapeutic Class
Gastrointestinal protectants – Chelating complex
✔️ Dosage & Administration
For Duodenal & Gastric Ulcers, Chronic Gastritis:
Adults: 2 g twice daily (morning and bedtime), or 1 g four times daily (one hour before meals and at bedtime).
Maximum daily dose: 8 g.
Treatment may continue up to 12 weeks in resistant cases.
For Stress Ulcer Prophylaxis:
Adults: 1 g, 4 to 6 times daily, orally or via nasogastric tube.
Follow each nasogastric dose with 10 ml of water to prevent clogging.
Duration: As long as stress ulcer risk factors persist (typically not exceeding 14 days).
Take on an empty stomach. Avoid antacids within 30 minutes of taking Ulfix.
Children (<14 years): Safety and efficacy not established.
Elderly: Use the lowest effective dose; no specific adjustment required.
Renal Impairment: Use cautiously due to the risk of aluminum accumulation.
✔️ Side Effects
Common Adverse Reactions:
- Headache (3.4%)
- Nausea, abdominal pain (2.3%)
- Constipation, diarrhea, urticaria (1.1%)
Others (Rare or Undefined Frequency):
- Dizziness, dry mouth, flatulence, indigestion, insomnia, vomiting, vertigo
- Bezoar formation (especially in patients with impaired gastric motility or on tube feeding)
- Hyperglycemia in diabetic patients
✔️ Drug Interactions
Ulfix may impair the absorption of several medications, including:
- Ciprofloxacin, Norfloxacin, Tetracyclines, Ketoconazole, Sulpiride, Digoxin, Warfarin, Phenytoin, Theophylline, Levothyroxine, Quinidine, and H2 blockers.
- To minimize interaction:
- Maintain a 2-hour interval between Ulfix and the above medications.
- Avoid co-administration with citrate-based preparations, which may enhance aluminum absorption.
- Separate Ulfix and enteral feeding by at least 1 hour to prevent bezoar formation.
✔️ Overdose
Overdose is generally well tolerated. Minor symptoms such as nausea, abdominal discomfort, or vomiting may occur. Animal studies show low toxicity even at high doses.
✔️ Contraindications
Known hypersensitivity to Sucralfate or any component of the formulation.
✔️ Precautions & Warnings
- Use with caution in renal impairment due to the risk of aluminum toxicity (osteomalacia, encephalopathy, anemia).
- Regular monitoring of serum aluminum, calcium, phosphate, and alkaline phosphatase is advised in long-term or high-dose therapy.
- Avoid combining with other aluminum-containing products.
- Risk of bezoar formation in patients with delayed gastric emptying or on enteral feeding.
- Use with caution in pregnancy and breastfeeding; safety not well established.
✔️ Storage Conditions
Store below 25°C in a cool, dry place away from direct light. Keep out of reach of children.
Disclaimer:
ePharma sole intention is to ensure that its consumers get proper
information as musch as possible. Although we do not guarantee the
accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
intend to support, not replace, the doctor-patient relationship.
